阿尔茨海默病的发病机制及相关治疗

论文发表：

[1] Wang Y, Wang Q, Chen J, Yao LH, Tang N, Jiang ZX, Luo Y. Protective Effect of Hydroxysafflor Yellow A against Chronic Mild Stress-induced Memory Impairments by Suppressing Tau Phosphorylation in Mice. Curr Med Sci. 2021 Jun;41(3):555-564.

[2] Feng Q, Luo Y, Zhang XN, Yang XF, Hong XY, Sun DS, Li XC, Hu Y, Li XG, Zhang JF, Li X, Yang Y, Wang Q, Liu GP, Wang JZ. MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration. Autophagy. 2020 Apr;16(4):641-658.

[3] Luo Y, Nie YJ, Shi HR, Ni ZF, Wang Q, Wang JZ, Liu GP .PTPA activates protein phosphatase-2A through reducing its phosphorylation at tyrosine-307 with upregulation of protein tyrosine phosphatase 1B. Biochim Biophys Acta. 2013 May;1833(5):1235-43.

[4]Luo Y, Jiang W, Da Z, Wang B, Hu L, Zhang Y, An R, Yu H, Sun H, Tang K, Tang Z, Wang Y, Jing T, Zhu B. Subunit vaccine candidate AMM down-regulated the regulatory T cells and enhanced the protective immunity of BCG on a suitable schedule. Scand J Immunol. 2012 Mar;75(3):293-300.

[5]Luo Y, Wang B, Hu L, Yu H, Da Z, Jiang W, Song N, Qie Y, Wang H, Tang Z, Xian Q, Zhang Y, Zhu B. Fusion protein Ag85B-MPT64(190-198)-Mtb8.4 has higher immunogenicity than Ag85B with capacity to boost BCG-primed immunity against Mycobacterium tuberculosis in mice. Vaccine. 2009 Oct 19;27(44):6179-85

其他：

参与完成的译著一部：《结核病学-基础与临床》（36365线路检测中心出版社），字数3.万字；国家知识产权局授权专利一项：卡介苗多糖核酸-DDA佐剂的制备及应用（专利号：200710163447），排名5/11。

社会工作：

任甘肃省生理科学会第十五届理事会理事。