孙旺盛

职  务:新药设计与合成教研室副主任

职  称:青年教授、博士生导师

电子邮箱:sunws@lzu.edu.cn

科研方向:多肽药物化学与药理学

       孙旺盛,博士,36365线路检测中心/甘肃省新药临床前研究重点实验室青年教授,博士生导师。2009年毕业于36365线路检测中心生命科学学院,获学士学位,2014年获生物化学与分子生物学专业博士学位,师从王锐院士。2014年7月至今,在36365线路检测中心从事教学科研工作,甘肃省新药临床前研究重点实验室骨干成员,教育部“多肽药物”创新团队、中国医学科学院多肽研究创新单元核心骨干成员。

       围绕多肽创新药物研发开展研究工作,取得了一系列进展。研究成果在国际高水平期刊累计发表学术论文50余篇,受到国际同行广泛关注,被SCI引用2800余次,其中两篇论文被评为领域中的高被引论文(Web of Science);已授权国家发明专利5项,在申请2项;参编英文专著1章,获教育部自然科学一等奖(排名12/15,2014)、甘肃省“优秀药学工作者”(2019)等奖励。

受教育经历:

2009.09-2014.06 36365线路检测中心 生命科学学院生物化学与分子生物学,博士

2005.09-2009.0636365线路检测中心 生命科学学院生物技术基地班,学士

工作经历:

2017.05-至今 36365线路检测中心、甘肃省新药临床前研究重点实验室 副教授、硕士生导师

2014.07-2017.05 36365线路检测中心、甘肃省新药临床前研究重点实验室讲师

 

多肽药物化学与药理学

主持科研项目:

1、国家自然科学基金青年基金(NSFC21502079)1项, 2016.01-2018.12。

2、中央高校基本科研业务费面上项目lzujbky-2015-163,2015.01-2016.06。

3、中央高校基本科研业务费面上项目lzujbky-2015-278,2015.07-2016.12。

近五年代表性论文:

1.  Orthogonal bioconjugation targeting cysteine-containing peptides and proteins using alkyl thianthrenium salts Bao, Guangjun; Song, Xinyi; Li, Yiping; He, Zeyuan; Zuo, Quan; E, Ruiyao; Yu, Tingli; Li, Kai; Xie, Junqiu*; Sun, Wangsheng*; Wang, Rui*Nat. Commun.2024151),6909。(IF = 14.7

2.    Cysteine-Specific Multifaceted Bioconjugation of Peptides and Proteins Using 5-Substituted 1,2,3-TriazinesZuo, Quan; Li, Yiping; Lai, Xuanliang; Bao, Guangjun; Chen, Lu; He, Zeyuan; Song, Xinyi; E, Ruiyao; Wang, Pengxin; Shi, Yuntao; Luo, Huixin; Sun, Wangsheng*; Wang, Rui*Adv. Sci.20241121),2308491。(IF = 14.3

3.    Intermolecular sulfur atom transfer cascade enabled late-stage introduction of sulfilimines into peptides He, Zeyuan; Liu, Yuyang; Bao, Guangjun; Li, Yiping; Zhao, Xiufang; Zuo, Quan; Li, Kai; Sun, Wangsheng*; Wang, RuiChem. Sci.202415, 17058-17063。(IF = 7.6

4.    Late-stage peptide modification and macrocyclization enabled by tertiary amine catalyzed tryptophan allylationLiu, Yuyang; Li, Guofeng; Ma, Wen; Bao, Guangjun; Li, Yiping; He, Zeyuan; Xu, Zhaoqing*; Wang, Rui*; Sun, Wangsheng*; Chem. Sci.2024, 15(28)11099-11107。(IF = 7.6

5.    Dimethyl Sulfoxide/Visible-Light Comediated Chemoselective C-S Bond Formation Between Tryptophans and Thiophenols Enables Site-Selective Functionalization of PeptidesBao, Guangjun; Wang, Peng; Li, Jingyue; Song, Xinyi ; Yu, Tingli; Zhang, Jiao; Li, Yiping; He, Zeyuan;  E Ruiyao; Miao, Xiaokang; Xie, Junqiu; Ni, Jingman*; Wang, Rui*; Sun, Wangsheng*CCS Chem.202466),1547-1556。(IF = 9.4

6.    Novel antimicrobial peptides modified with fluorinated sulfono-γ-AA having high stability and targeting multidrug-resistant bacteria infectionsGuo, Xiaomin; Miao, Xiaokang; An, Yingying; Yan, Tiantian; Jia, Yue; Deng, Bochuan; Cai, Jianfeng; Yang, Wenle; Sun, Wangsheng*; Wang, Rui*; Xie, Junqiu*Eur. J.  Med. Chem.2024264116001。(IF = 6.0

7.    Novel Feleucin-K3-Derived Peptides Modified with Sulfono-γ-AA Building Blocks Targeting Pseudomonas aeruginosa and Methicillin- Resistant Staphylococcus aureus InfectionsGuo, Xiaomin; Yan, Tiantian; Rao, Jing; An, Yingying; Yue, Xin; Miao, Xiaokang; Wang, Rui; Sun, Wangsheng*; Cai, Jianfeng*; Xie, Junqiu*J. Med. Chem.2023662),1254-1272。(IF = 6.8

8.    NDTP Mediated Direct Rapid Amide and Peptide Synthesis without EpimerizationLi, Yiping; Li, Jingyue; Bao, Guangjun; Yu, Changjun; Liu, Yuyang; He, Zeyuan; Wang, Peng; Ma, Wen; Xie, Junqiu; Sun, Wangsheng*; Wang, Rui*Org. Lett.2022245),1169-1174。(IF = 4.9

9.    1,3-Dipolar Cycloaddition between Dehydroalanines and C,N-Cyclic Azomethine Imines: Application to Late-Stage Peptide ModificationBao, Guangjun; Wang, Peng; Li, Guofeng; Yu, Changjun; Li, Yiping; Liu, Yuyang; He, Zeyuan; Zhao, Tiantian; Rao, Jing; Xie, Junqiu; Hong, Liang; Sun, Wangsheng*; Wang, Rui*Angew. Chem. Int. Ed.20216010),5331-5338。(IF = 16.1

10. Organocatalytic Enantioselective Synthesis of Tetrasubstituted α-Amino Allenoates by Dearomative γ-Addition of 2,3-Disubstituted Indoles to β,γ-Alkynyl-α-imino EstersYang, Junxian; Wang, Zheng; He, Zeyuan; Li, Guofeng; Hong, Liang; Sun, Wangsheng* Wang, Rui*Angew. Chem. Int. Ed.2020592),642-647。(IF = 16.1