多肽修饰、不对称合成、小分子及多肽药物

主持科研项目：

1. “双一流”引导专项-队伍建设经费-科研启动费，2020.03-2025.03（在研）；
2. 国家自然科学基金青年基金项目，批准号：22001103，2021.01-2023.12（已结题）；
3. 国家自然科学基金面上项目，批准号：22371099，2024.01-2027.12（在研）；
4. 甘肃省自然科学基金青年科技基金，批准号：23JRRA1115，2023.07-2025.06（在研）。

发表论文

1. Anqi Chu, Boyan Zhu, Xiaoyong Zhang, Hanwen Zhu, Jingying Zhang, Xihong Liu*, Catalytic kinetic resolution of helical polycyclic phenols via an organocatalyzed enantioselective dearomative amination reaction. Sci. Adv., 2024, in press. (SCI一区, IF₂₀₂₃ = 13.6)
2. Xihong Liu*, Boyan Zhu, Xiaoyong Zhang, Hanwen Zhu, Jingying Zhang, Aiqi Chu, Fujun Wang and Rui Wang*, Enantioselective synthesis of [4]helicenes by organocatalyzed intermolecular C-H amination. Nat. Commun., 2024, 15, 732-743. (SCI一区, IF₂₀₂₃ = 16.6)
3. Xihong Liu*, Boyan Zhu, Panpan Zhou, Jingying Zhang, Anqi Chu and Rui Wang*, Organocatalyzed double dearomatization reaction of non-functionalized phenols and propargylic alcohols: the important regulating effect of steric hindrance. Org. Chem. Front., 2024, 11, 3516-3524. (SCI一区, IF₂₀₂₃ = 5.4; Outside front cover)
4. Xihong Liu, Jingying Zhang, Lutao Bai, Linqing Wang, Dongxu Yang* and Rui Wang*, Catalytic asymmetric multiple dearomatizations of phenols enabled by a cascade 1,8-addition and Diels–Alder reaction. Chem. Sci., 2020, 11, 671-676. (SCI一区, IF₂₀₂₃ = 8.4; Inside back cover)
5. Xihong Liu, Pengxin Wang, Lutao Bai, Dan Li, Linqing Wang*, Dongxu Yang and Rui Wang*, Construction of Vicinal All-Carbon Quaternary Stereocenters Enabled by a Catalytic Asymmetric Dearomatization Reaction of β‑Naphthols with 3‑Bromooxindoles. ACS Catal., 2018, 8, 10888-10894. (SCI一区, IF₂₀₂₃ = 12.9)
6. Xihong Liu, Dongxu Yang, Kezhou Wang, Jinlong Zhang and Rui Wang*, A catalyst-free 1,3-dipolar cycloaddition of C,N-cyclic azomethine imines and 3-nitroindoles: an easy access to five-ring-fused tetrahydroisoquinolines. Green Chem., 2017, 19, 82-87. (SCI一区, IF₂₀₂₃ = 9.8)
7. Xihong Liu^#, Yijie Wang^#, Dongxu Yang, Jinlong Zhang, Dongsheng Liu* and Wu Su*, Catalytic Asymmetric Inverse-Electron-Demand 1,3-Dipolar Cycloaddition of C,N-Cyclic Azomethine Imines with Azlactones: Access to Chiral Tricyclic Tetrahydroisoquinolines. Angew. Chem. Int. Ed., 2016, 55, 8100-8103. (SCI一区, IF₂₀₂₃ = 16.6)
8. Xihong Liu^#, Jinlong Zhang^#, Long Zhao, Shixiong Ma, Dongxu Yang, Wenjin Yan and Rui Wang*, Construction of Vicinal Tetrasubstituted Stereocenters with a C−F Bond through a Catalytic Enantioselective Detrifluoroacetylative Mannich Reaction. J. Org. Chem., 2015, 80, 12651-12658. (SCI二区, IF₂₀₂₃ = 3.6)
9. Xihong Liu, Jinlong Zhang, Shixiong Ma, Yunxia Ma and Rui Wang*, Oxidative cross-dehydrogenative coupling between N-aryl tetrahydroisoquinolins and 5H-oxazol-4-ones through two methodologies: copper catalysis or a metal-free strategy. Chem. Commun., 2014, 50, 15714-15717. (SCI二区, IF₂₀₂₃ = 4.9)
10. Jinlong Zhang^#, Xihong Liu^# and Rui Wang*, Magnesium Complexes as Highly Effective Catalysts for Conjugate Cyanation of α,β-Unsaturated Amides and Ketones. Chem. Eur. J., 2014, 20, 4911-4915. (SCI二区, IF₂₀₂₃ = 4.3)
11. Jinlong Zhang, Xihong Liu, Chongyang Wu, Panpan Zhang, Jianbo Chen and Rui Wang*, Organocatalyzed Asymmetric 1,4-Addition of Azlactones to α,β-Unsaturated Trichloromethyl Ketones: Synthesis of α,α-Disubstituted α-Amino Acid Derivatives. Eur. J. Org. Chem., 2014, 7104–7108. (SCI三区, IF₂₀₂₃ = 2.8)
12. Jinlong Zhang, Xihong Liu, Xiaojuan Ma and Rui Wang*, Organocatalyzed asymmetric vinylogous Michael addition of α,β-unsaturated γ-butyrolactam. Chem. Commun., 2013, 49, 9329-9331. (SCI二区, IF₂₀₂₃ = 4.9)
13. Jinlong Zhang, Xihong Liu, Xiaojuan Ma and Rui Wang*, Direct asymmetric aldol addition-isomerization of α,β-unsaturated γ-butyrolactam with aryl γ-ketoesters: synthesis of MBH-type products. Chem. Commun., 2013, 49, 3300-3302. (SCI二区, IF₂₀₂₃ = 4.9)
14. Kezhou Wang^#, Chao Chen^#*, Xihong Liu, Dan Li, Tianyu Peng, Xin Liu, Dongxu Yang and Linqing Wang*, Enantioselective Reaction between 2‑(Cyanomethyl)azaarenes and N‑Boc-amino Sulfones. Org. Lett., 2018, 20, 5260-5263. (SCI一区, IF₂₀₂₃ = 5.2)
15. Kezhou Wang, Linqing Wang, Xihong Liu, Dan Li, Haiyong Zhu, Pengxin Wang, Yuyang Liu, Dongxu Yang* and Rui Wang*, Development of Biligands Magnesium Catalysis in Asymmetric Conjugate Reactions of C3-Pyrrolyl-Oxindoles. Org. Lett., 2017, 19, 4351-4354. (SCI一区, IF₂₀₂₃ = 5.2)
16. Linqing Wang^#, Dongxu Yang^#, Dan Li, Xihong Liu, Qian Zhao, Ranran Zhu, Bangzhi Zhang and Rui Wang*, Catalytic Asymmetric [3+2] Cyclization Reactions of 3‑Isothiocyanato Oxindoles and Alkynyl Ketones Via an in Situ Generated Magnesium Catalyst. Org. Lett., 2015, 17, 4260-4263. (SCI一区, IF₂₀₂₃ = 5.2)
17. Dan Li, Dongxu Yang*, Linqing Wang, Xihong Liu, Kezhou Wang, Jie Wang, Pengxin Wang, Yuyang Liu, Haiyong Zhu and Rui Wang*, An Efficient Nickel-Catalyzed Asymmetric Oxazole-Forming Ugi-Type Reaction for the Synthesis of Chiral Aryl-Substituted THIQ Rings. Chem. Eur. J., 2017, 23, 6974-6978. (SCI二区, IF₂₀₂₃ = 4.3)
18. Dan Li, Dongxu Yang*, Linqing Wang, Xihong Liu, Xianxing Jiang* and Rui Wang*, Mg^II-Catalyzed Desymmetrization Reaction of meso-Aziridines with Hydroxylamines: Synthesis of Novel Chiral 1,2-Diamine Skeletons. Chem. Eur. J., 2016, 22, 17141-17144. (SCI二区, IF₂₀₂₃ = 4.3)
19. Linqing Wang, Dongxu Yang*, Dan Li, Xihong Liu, Pengxin Wang, Kezhou Wang, Haiyong Zhu, Lutao Bai and Rui Wang*, The Important Role of the Byproduct Triphenylphosphine Oxide in the Magnesium(II)-Catalyzed Enantioselective Reaction of Hemiacetals and Phosphorus Ylides. Angew. Chem. Int. Ed., 2018, 57, 9088-9092. (SCI一区, IF₂₀₂₃ = 16.6)
20. Qiao Chen, Jiawei Zhou, Yanan Wang, Chao Wang, Xihong Liu, Zhaoqing Xu*, Li Lin and Rui Wang*, Transition-Metal-Free Dehydrosilylative Difluoroamidation of Tetrahydroisoquinolines under Mild Conditions. Org. Lett., 2015, 17, 4212-4215. (SCI一区, IF₂₀₂₃ = 5.2)