1、病原微生物共感染，微生物共培养，以及微生物相互作用机制。

2、病原微生物与宿主的相互作用及宿主的免疫响应机制。

科研项目（课题）

   主持国家自然科学基金青年项目（1项，2021-2023年），面上项目（1项，2024-2027年）

代表性文章

1. Gou,Y., Liu, D., Xin,Y., Wang,T., Li, J., Xi,Y., Zheng, X., Che, T., Zhang, Y., Li, T. * and Feng, J. * (2024). " Viable but Nonculturable State in the Zoonotic Pathogen Bartonella henselae Induced by Low-Grade Fever Temperature and Antibiotic Treatment." Front Cell Infect Microbiol (Accepted).
2. Feng, J., Li, J., Liu, D., Xin, Y., Sun, J., Yin, W.-B. & Li, T*. Generation and comprehensive analysis of Synechococcus elongatus–Aspergillus nidulans co-culture system for polyketide production. Biotechnol Biofuels 16, 32, (2023).
3. Jin, X., Y. Gou, Y. Xin, J. Li, J. Sun, Li, T.* and Feng, J. * (2023). Advancements in understanding the molecular and immune mechanisms of Bartonella pathogenicity. Front Microbiol 14: 1196700.
4. Li, T., Xin, Y., Liu, D., Sun, J., Li, J., Zhang, Y. & Feng, J. High-throughput Drug Screening on Borrelia garinii and Borrelia afzelii Identified Hypocrellin A as an Active Drug Candidate Against Borrelia Species. Infect Microbes Dis, 5(2):83-92 (2023).
5. Li, T., Pang, N., He, L., Xu, Y., Fu, X., Tang, Y., Shachar-Hill, Y. & Chen, S. Re-Programing Glucose Catabolism in the Microalga Chlorella sorokiniana under Light Condition. Biomolecules 12, 939 (2022).
6. Li, T., Jiang, L. Q., Hu, Y. F., Paul, J. T., Zuniga, C., Zengler, K. & Betenbaugh, M. J. Creating a synthetic lichen: Mutualistic co-culture of fungi and extracellular polysaccharide-secreting cyanobacterium Nostoc PCC 7413. Algal Res 45, 101755 (2020).
7. Li, T., Liu, D., Yang, Y., Guo, J., Feng, Y., Zhang, X., Cheng, S. & Feng, J. Phylogenetic supertree reveals detailed evolution of SARS-CoV-2. Sci Rep 10, 22366, (2020).
8. Li, T., Feng, J., Xiao, S., Shi, W., Sullivan, D. & Zhang, Y. Identification of FDA-Approved Drugs with Activity against Stationary Phase Bartonella henselae. Antibiotics (Basel) 8, (2019).
9. Li, T., Li, C. T., Butler, K., Hays, S. G., Guarnieri, M. T., Oyler, G. A. & Betenbaugh, M. J. Mimicking lichens: incorporation of yeast strains together with sucrose-secreting cyanobacteria improves survival, growth, ROS removal, and lipid production in a stable mutualistic co-culture production platform. Biotechnol Biofuels 10, 55 (2017).
10. Li, T., Kirchhoff, H., Gargouri, M., Feng, J., Cousins, A. B., Pienkos, P. T., Gang, D. R. & Chen, S. Assessment of photosynthesis regulation in mixotrophically cultured microalga Chlorella sorokiniana. Algal Res 19, 30-38, (2016).
11. Li, T., Gargouri, M., Feng, J., Park, J. J., Gao, D., Miao, C., Dong, T., Gang, D. R. & Chen, S. Regulation of starch and lipid accumulation in a microalga Chlorella sorokiniana. Bioresour Technol 180, 250-257, (2015).
12. Li, T., Zheng, Y., Yu, L. & Chen, S. Mixotrophic cultivation of a Chlorella sorokiniana strain for enhanced biomass and lipid production. Biomass Bioenerg 66, 204-213 (2014).
13. Li, T., Zeng, J., Singh, D., & Chen, S. New insights into the role of termite Coptotermes formosanus inhabiting Streptomyces in degradation of lignin. J Bioremediat & Biodegrad, 5:220. (2014)
14. Li, T., Zheng, Y., Yu, L. & Chen, S. High productivity cultivation of a heat-resistant microalga Chlorella sorokiniana for biofuel production. Bioresour Technol 131, 60-67, (2013).
15. Zuniga, C., Li, T., Guarnieri, M. T., Jenkins, J. P., Li, C. T., Bingol, K., Kim, Y. M., Betenbaugh, M. J. & Zengler, K. Synthetic microbial communities of heterotrophs and phototrophs facilitate sustainable growth. Nat Commun 11, 3803, (2020).
16. Yu, L., Li, T., Ma, J., Zhao, Q., Wensel, P., Lian, J. & Chen, S. A kinetic model of heterotrophic and mixotrophic cultivation of the potential biofuel organism microalgae Chlorella sorokiniana. Algal Res 64, 102701 (2022).
17. Jiang, L., Li, T., Jenkins, J., Hu, Y., Brueck, C., Pei, H. & Betenbaugh, M. J. Evidence for a mutualistic relationship between the cyanobacteria Nostoc and fungi Aspergilli in different environments. Appl Microbiol Biot 104, 6413-6426, (2020).
18. Feng, J., Li, T., Yee, R., Yuan, Y., Bai, C., Cai, M., Shi, W., Embers, M., Brayton, C., Saeki, H., Gabrielson, K. & Zhang, Y. Stationary Phase Persister/Biofilm Microcolony of Borrelia burgdorferi Causes More Severe Disease in a Mouse Model of Lyme Arthritis: Implications for Understanding Persistence, Post-Treatment Lyme Disease Syndrome (PTLDS), and Treatment Failure. Discov Med 27, 125-138 (2019).
19. Zheng, Y., Li, T., Yu, X., Bates, P., Dong, T. & Chen, S. High-density fed-batch culture of a thermotolerant microalga Chlorella sorokiniana for biofuel production. Appl Energ 108, 281-287, (2013).